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Chan School of Public Health, (5)University of California, San Francisco, (6)Boehringer Ingelheim Pharmaceuticals, (7)Iccb-Longwood Screening Facility, Harvard Medical School, (8)Broad Institute Background: Chronic liver injury leads to hepatic stellate cell (HSC) activation and transdifferentiation into HSC myofibroblasts, which produce the extracellular matrix (ECM) responsible for fibrosis

Puneeta P, Vijai D, Yamamoto J, Sakurai Y (2018) Orientation patterns of Japanese flying squid Todarodes pacificus embryos within egg masses and responses of paralarvae to light

UNCs Relink project has highlighted these gaps and the need for interventions to link untreated patients to care

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Vitamin B1 (Thiamin) Thiamin is a potent free radical scavenger that regulates intracellular glucose and prevents polyol pathway activation, which is induced by high intracellular glucose [65, 66]

Studies have shown that autophagy exacerbates liver fibrosis by breaking down lipid droplets in HSCs, thereby activating the HSCs