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AOD-9604 operates independently of GH receptors and doesn't engage the broader GH signaling cascade that produces IGF-1 elevation

Of note, none of the animals exhibited LASV nAb antibodies prior to challenge as previously observed (Figure S6E, compare to Figure S4D)

In a 72-week clinical study, adults using tirzepatide alongside lifestyle modifications lost an average of 20% of their body weight

When they become active, cell death is essentially inevitable

Same lipolytic core mechanism

AOD9604 has been studied in preclinical and early clinical settings, and it received GRAS (Generally Recognized as Safe) designation from the US FDA for use as a food ingredient