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In 2022, 389,485 new OSCC cases and 188,230 related deaths were reported worldwide, yielding a case-fatality rate of 48%, and its incidence continues to rise annually ( 2 Research progress on ferroptosis in OSCC 2.1 Mechanisms of ferroptosis Ferroptosis is a regulated form of cell death driven by the iron-dependent accumulation of lethal lipid peroxides

Lysosomal membrane stability is crucial for cellular homeostasis

This remains an active area of interest in melanocortin system research

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Dox was used at 10 mg/kg, which was chosen based on previous work demonstrating lasting changes to the ovarian reserve (Ben-Aharon et al, 2010)

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