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Due to the short-term exposure to NAs (24 h) in the present study, the in vitro alkaline comet assay likely detected mainly DNA N -alkylation damage and its subsequent repair by base excision repair (BER)

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Validation of the metabolic capabilities of phase specific AM GSM models The E-flux models were next validated to ensure their ability to simulate biologically significant processes by reproducing important metabolite production rates and characteristic behavior as reported in literature