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Saudi J Kidney Dis Transpl

20000 Rs

Higher intestinal permeability induces the translocation of gut bacteria and microbial components that initiate inflammation and oxidative stress in the enteric nervous system, resulting in enteric -synucleinopathy in PD (Bjarnason et al., Inflammation of the gut and neuroinflammation of the brain The maturation and function of microglia are affected by the altered cell proportions, while immature phenotypes are based on the circulating levels of pro-inflammatory and anti-inflammatory cytokines contributing to host homeostasis (Erny et al., via TLRs activation (Lucas and Maes, 2013)

Sleep diaries provide valuable longitudinal data on sleep patterns and help identify trends and potential triggers, whereas their accuracy is inherently dependent on patient or caregiver perception

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