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The downregulation of SIRT1 diminishes the inhibitory effect of vitamin K-2 (VK2) on ferroptosis in BMSCs exposed to high glucose, consequently contributing to bone loss ( 2.4 The relationship between ferroptosis and different clinical subtypes of osteoporosis The clinical subtypes of osteoporosis primarily include postmenopausal osteoporosis, diabetic osteoporosis, glucocorticoid-induced osteoporosis, and thalassemia-related osteoporosis

Moreover, we further identified P300 as the main succinylation-catalyzing enzyme of GCLC, and their association showed a remarkable decrease upon ROS treatment

Although the role of NO in regulating adipocyte differentiation is still unclear, a similar mechanism has been proposed to be responsible for the upregulation of adipocyte differentiation leading to the development of obesity

ALA may affect blood sugar and should be supervised in diabetic patients

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2007), transient receptor potential channels (TRPC) (Vohra et al