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For this purpose, we employed a systems metabolomics approach to comprehensively profile and identify metabolic alteration in ALS mouse epSPCs at distinct stages of disease development and progression

Discussion Nucleotide synthesis is a demanding task that consumes numerous metabolic resources

The acute response initiation involves changes in blood flow stimulated by prostaglandin E2 and prostaglandin I2, while leukotriene B4, produced from arachidonic acid, stimulates the recruitment of polymorphonuclear leukocytes

Among them, the cGAS-STING signaling pathway plays a dual role in tumor immunity: it can suppress anti-tumor immunity to promote cancer progression, or enhance tumor antigen presentation to exert an anti-tumor effect

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Research in 2026 suggests that elevated NNMT activity, common in aging and metabolic dysfunction, can deplete NAD+