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W.MithenR.et al (2019)

But as you unpack your medication, a common question arises: "Does this need to go in the fridge?" The short answer is: Yes, usually

Clinical trials show patients who discontinue treatment regain approximately two-thirds of lost weight over the following year, while A1C levels typically rise as the medication's metabolic effects cease

Cell 175 , 502513.e513 (2018)

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Body mass index and the visceral adipose tissue expression of IL-6 and TNF-alpha are associated with the morphological severity of non-alcoholic fatty liver disease in individuals with class III obesity