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In the absence of a definitive cause for IBD, and hence a cure, novel and often nuanced aspects of disease pathophysiology continue to be uncovered

HO-1, heme oxygenase-1

Andre T, Lonardi S, Wong M, Lenz HJ, Gelsomino F, Aglietta M, Morse M, Van Cutsem E, McDermott RS, Hill AG, Sawyer MB, Hendlisz A, Neyns B, Svrcek M, Moss RA, Ledeine JM, Cao ZA, Kamble S, Kopetz S , Overman MJ

REDEFINE 1 trial results: 91.9% of participants achieved 5% body weight reduction vs 31.5% in the placebo group

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During the examination ultrasound showed pathological zone near the right lobe of thyroid gland 9 5*7 mm (parathyroid gland?) Later laboratory investigations confirmed raised serum calcium 2.82 mmol/L, increased PTH 24.82 pmol/l (1.4510.41) and deficiency 25-hydroxyvitamin D21 nmol/l