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Butyrate, which is a short-chain fatty acid produced by beneficial bacteria in the colon, improves Treg cell function too, so prebiotics can actually do that indirectly

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Aberrant binding of HDACs at specific promoter regions suppresses normal functional gene transcription, inducing malignancy, such as promyelocytic leukemiaretinoic acid receptor- (PMLRAR) fusion proteins that reactivate HDACs and inhibit the expression of genes associated with hematopoietic cell differentiation, leading to the progression of acute promyelocytic leukemia (APL) 70

Fatty tissue is also known to synthesize leptin