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In addition to alleviating neurodegeneration, treadmill exercise effectively reduced anxiety, enhanced spatial memory recovery, and improved social novelty post TBI

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Therefore, more interventions and experimental studies are needed to address the existing knowledge gaps ( Statements Author contributions DY, FC, and XL contributed to the conception, writing, and editing of this manuscript

This positions GSH as an abundant intermediate carrier that forms a large, exchangeable Cu + pool, buffering copper ions between cellular uptake and delivery to high-affinity protein targets

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