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Additionally, in response to the commenter's request for clarity regarding whether we plan to implement any changes to the HCC risk adjustment process, we note that the HEBA is an upward adjustment to an ACO's historical benchmark that does not change or otherwise impact adjustments for changes in severity and case mix using prospective HCC risk scores when establishing or adjusting the benchmark as described in 425.652(a)(3), (a)(9), and (a)(10)

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The need for NSAIDs (nonsteroidal anti-inflammatory drugs) or COX-2 inhibitors was high at inclusion with 23.7 8.2 and 25.1 9.7 pills per month for each subject in the placebo and in the Pycnogenol group, respectively

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