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Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

Once in the cytosol, Glu and Cys are combined into the dipeptide -glutamylcysteine (-GC) by the enzymatic activity of glutamatecysteine ligase (GCL), which requires ATP and Mg 2+ as co-substrates (Figure 2A) [15,16,17]

In addition, this sequence has shown to have good reproducibility for the measurement of GABA, GSH and Glx (DeMayo et al., 2025)

Xia N, Daiber A, Forstermann U, Li H

I.MartinezA.NilsenF.DondrupM

Of these genes, EtOH feeding up-regulated Fads1 and down-regulated Acox1 genes in WT mice, a result in agreement with the observed increase in total TG content