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Antioxidants (Basel) 10 (3), 364

Abbreviations GSH glutathione SH sulfhydryl group O 2 superoxide H 2 O 2 hydrogen peroxide NOX NADPH oxidase SOD superoxide dismutase HOCl hypochlorous acid HOBr hypobromous acid Fe 2+ ferrous iron OH hydroxyl radical Fe 3+ ferric iron L lipid radical LOO hydroperoxide radical LOOH lipid peroxide HNE 4-hydroxy-2-nonenal ONOO peroxynitrite NO nitrogen oxide nitrite nitrate ONOOH peroxynitrous acid NO 2 nitrogen dioxide CFTR cystic fibrosis transport receptor GPx glutathione peroxidase PHGPx GPx IV phospholipid hydroperoxide glutathione peroxidase GSSG glutathione disulfide Prdx peroxiredoxin PSSG protein mixed disulfide PDI protein disulfide isomerase S thiolate PSOH sulfenic acid GST glutathione-S transferase GSNO nitrosoglutathione DTNB dithionitrobenzoic acid NEM N-ethylmaleimide NaBH 4 sodium borohydride OPT orthophthaldehyde GCL glutamate cysteine ligase ARE antioxidant response element JNK Jun N-terminal kinase GGT -glutamyl transpeptidase

El-Batal et al

Fermented extracts exhibited increased DPPH and ABTS radical-scavenging capacities and significantly reduced nitric oxide production from day six of fermentation

Scientific Overview: Dihexa is a synthetic hexapeptide analogue known for its high affinity to hepatocyte growth factor (HGF) receptors, extensively studied in molecular biology research for its capacity to modulate neurotrophic signalling pathways

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