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check their B12 status, and request it to be checked if it is not available, ensure the levels are more than 300 pmol/L and not above the recommended upper limit, recommend reducing frequency of the intervention if the levels are at the high end of normal range or above range

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The studies tested various doses including 0.25 mg, 0.5 mg, and 1 mg daily via subcutaneous administration over periods ranging from single doses to 24 weeks of continuous therapy