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Acknowledgements The authors wish to acknowledge the editorial support of Adriana Barbat and Corey Astrom, ELS, who were instrumental in the preparation and professional development of this paper

doi: 10.3389/fphys.2023.1281071 Received 21 August 2023 Accepted 16 October 2023 Published 31 October 2023 Volume 14 - 2023 Edited by Maria Cavinato, University of Innsbruck, Austria Reviewed by Eleni Mavrogonatou, National Centre of Scientific Research Demokritos, Greece Raghvendra K

Standard Dosing Range For skin rejuvenation and addressing loose skin, typical protocols involve 1 to 2 mg of GHK-Cu daily via subcutaneous injection

The substrates for these reactions are both endogenous (intrinsic) and exogenous (xenobiotics), being mainly electrophiles, Michael acceptors, epoxides, electron-withdrawing structures and carbonyls, which are able to react through nucleophilic additions with GSH

Key factors include: Repetitive jumping or running on hard surfaces Sudden increase in training intensity, frequency, or duration Poor training technique, inadequate warm-up, or muscle imbalances Tight or inflexible quadriceps and hamstrings Weakness in glute or core muscles Inadequate footwear or improper support during exercise Previous knee injury, chronic illness, or underlying structural issues Athletes in jumping or sprinting sports, as well as those returning from a period of inactivity too quickly, are especially at risk