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The rationale for combining these three peptides extends beyond simple additive effects to encompass true biological synergy, where coordinated activation of complementary pathways produces outcomes unattainable by individual components alone

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Nature (2017) 547(7661):1048

Unraveling the genetic susceptibility of migraine phenotypes and features could potentially contribute to disease diagnosis, to more accurate understanding of disease pathophysiology, and eventually to the identification of novel targets for therapeutic treatment