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[DOI] [PubMed] [Google Scholar] 29.Perelman M.A

Brakedal, B

Dopytalska K, Ciechanowicz P, Wiszniewski K, Szymaska E, Walecka I

Polymeric micelles amplify tumor oxidative stresses through combining PDT and glutathione depletion for synergistic cancer chemotherapy

Long-term survival outcomes of metabolically supported chemotherapy with gemcitabine-based or FOLFIRINOX regimen combined with ketogenic diet, hyperthermia, and hyperbaric oxygen therapy in metastatic pancreatic cancer

Below is a hypothetical scenario to demonstrate my point: An individual suffers from long-term thiamine deficiency and has suboptimal riboflavin status Thiamine deficiency leads to lower activity of transketolase Low transketolase activity produces a lack of NADPH A lack of NADPH and a lack of FAD means that glutathione reductase is unable to efficiently recycle glutathione, which produces an imbalance between reduced/oxidized glutathione