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Furthermore, epigenetic alterations within germ cells pose multigenerational adverse effects on the reproductive system

356 Synergistic effects are observed when MSCs are combined with conventional therapies, such as GLP-1RA exenatide 357 or SGLT-2I, such as empagliflozin, 358 which improve mitochondrial autophagy, podocyte protection, and renal function in diabetic rat models