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10.1016/j.jns.2003.11.005 51

15,16 Management of migraine would benefit from an approach that extends beyond pharmacotherapy alone, and identifies exacerbating factors and relevant comorbid conditions, examines past and current medications and other therapies, and a management plan with preventive, acute and lifestyle components as well as self-monitoring with a headache diary

The inhibition of mitochondrial respiration leads to depolarization of the IMM, followed by the opening of the mPTP and activation of apoptosis [170]

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Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome