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However, provided variations in the water content within the sample are much smaller than the variations in the metabolite levels, variance shared between normalized metabolite signals can be assumed to arise largely from shared variance in metabolite concentrations [52]

It is expected that proteins interacting with the compound of interest will be stabilized or destabilized, leading to a change in the temperature at which the target protein denatures and precipitates out of solution

Effect of long-term valproic acid administration on the efficiency of carnitine reabsorption in humans