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Summary Keywords glucose-6-phosphate dehydrogenase, G6PD, immunity, immunometabolism, G6PD deficiency Citation Shah SS, Stone EF, Francis RO and Karafin MS (2024) The global role of G6PD in infection and immunity

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Specifically, intracellular and extracellular PAMPs or DAMPs (e.g., viral dsDNA, bacterial lipopolysaccharide, extracellular ATP, ox-LDL, and cholesterol crystals) can promote inflammasome assembly and activation

The impact of ROS on HIF-1 influences key processes such as cellular inflammation, metabolism, and stress responses (Piantadosi and Suliman 2012)

Their skeleton comprises 2-phenyl--pyrone, which is involved in the heterocyclic pyrone ring connected with two phenyl rings [59]