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These findings allowed to stratify early psychosis patients in two subgroups: (a) patients with mitochondrial dysfunction characterized by exosomal high miR-137 and low COX6A2, presumably representing PV neuron dysfunction associated with mitochondria and (b) patients without mitochondrial dysfunction having miR-137 and COX6A2 levels within the healthy control range

Thus, preincubation with the glutathione inhibitor buthionine sulfoximine (BSO) induced massive cell death, whereas N -acetyl cysteine, a precursor of glutathione synthesis, improved the resistance to cisplatin treatment

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Therefore, lactate metabolism is undeniably important in TC

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