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Circulating cell-free DNA (cfDNA) is also a promising biomarker which can be detected in blood, stool or urine samples for cancer screening and estimating the therapeutic response, as well as identifying collateral damage in the tissues found in the proximity of the tumor, since DNA methylation can differentiate between malignant and non-malignant cells [70, 81]

Clinical Findings Animal studies demonstrate improved angiogenesis, faster wound closure, and reduced inflammation

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Furthermore, another study reported that combining methionine deprivation with a histone deacetylase 2 (HDAC2) inhibitor effectively reduced the level of the repressive histone mark H3K27me3 while increasing the level of the activating mark H3K27ac at the promoter of the epithelial marker E-cadherin