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The findings suggest that matrix effects were primarily caused by non-protein interferences, confirming effective deproteinization

These results correlate with previously published data, which have shown that stimulation of bFLS by bTNF- increases the expression of HIF-1, GLUT1 and PDK1, which favors a glycolytic metabolic phenotype-like 29

J Hazard Mater 416:125855 Tams MJ, Fauvet B, Christen P, Goloubinoff P (2018) Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo

Furthermore, CPT1A knockdown in breast cancer cells disrupts invasion and lymphangiogenesis of human dermal lymphatic ECs (HDLECs)

Using the nose-to-brain route to overcome listed pharmacokinetic challenges will allow future studies to better elucidate the neuroprotective efficacy of mitochondria-targeted drugs on CNS

Rufer AC, Thoma R, Benz J, Stihle M, Gsell B, De Roo E, et al