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Cell-permeable 2-OG treatment partially phenocopied the effects of ML226, consistent with perturbed OGDHc and 2-OG accumulation stabilizing HIF-1 and decreasing 5hmC levels (Fig

Aspects of the biogeochemistry of sulphur in glacial melt water ponds on the McMurdo Ice Shelf

In addition, the oral mucosa is in direct contact with the external environment and is prone to inflammation and oxidation, and prolonged inflammation that is difficult to suppress may lead to tissue necrosis and reduced function of the oral and maxillofacial area (Senel, 2021

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137 Collectively, the emerging role of lactylation in diseases is gaining clarity, with its changes potentially serving as diagnostic and prognostic markers and aiding in identifying therapeutic targets