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AOD-9604 appears to activate the same lipolytic pathway through a mechanism distinct from the classical GH receptor, which is why it doesn't trigger those anabolic/hormonal downstream effects

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Deletion of CD38 and Supplementation of NAD Attenuate Axon Degeneration in a Mouse Facial Nerve Axotomy Model

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Unlike fulllength hGH, AOD9604 does not meaningfully elevate IGF1 levels or worsen glucose tolerance, making its tolerability indistinguishable from placebo in human trials [2] [3]

Weeks 1-2: Metabolic Initiation During the first two weeks, the primary changes occur at the cellular level and may not be subjectively noticeable