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In addition, inflammation, ischemia, or tissue injury can lead to localized reductions in tissue perfusion, which may result in measurable decreases in regional temperature (3436)

During cellular respiration and ATP production in mitochondria, reactive oxygen species (ROS) are naturally produced in the electron transport chain (Subramaniam and Chesselet, 2013)

Growth spurt/puberty My daughter is really self-conscious of her skin, especially on thighs, after developing stretch marks due to her growth spurt during puberty

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Ethics approval statement The study was performed in accordance with the ARRIVE guidelines

If cause and severity are mild vitamin B12 deficiency may be managed via diet change or oral B12 supplements, especially if the cause of deficiency is poor intake