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Four different types of human glioma cell lines (LNT-229, LNT-308, LNT-428, and G55) were treated with selective mGluR5 antagonist (MPEP), mGluR1-specific antagonist (CPCCOE), and group I mGluRs (mGluR1 and mGluR5) agonist DHPG as a negative control

In the last few years, various GSH modulation-enhanced combinational therapy strategies have been extensively exploited, accompanied by the development of versatile metal-based nanosystems with different structures, functionalities, and treatment performances ( In view of the rapid development of GSH-responsive and -exhausting metal nanomedicines in potentiating cancer therapy, we summarize and outline the recent advancements, mechanisms, prospects, and challenges in this field from different strategies (Scheme 1)

Licata, L

The most convenient and safest method for patients to administer medicinal substances is oral administration

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GSH provides not only upregulation of VD regulatory genes but also adds to GLUT-4 activation