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doi: 10.1093/jmcb/mjy072 112 OhataYShimadaSAkiyamaYMogushiKNakaoKSatoshi MatsumuraSet al

NAD+ is the primary recommendation for: Patients with persistent fatigue, brain fog, or cognitive decline that tracks with aging rather than a specific metabolic cause

[3] In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, increased rate of haemolysis, and defective function of the central nervous system

It has also been hypothesized that IRP1 expression can be modulated to avoid cell death by ferroptosis (Zhang et al., 2022)

Silymarin prevents hepatocyte necrosis by maintaining biological membranes, promoting protein synthesis, scavenging free radicals, and raising glutathione levels