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In a clinical trial of secukinumab in 59 patients with severe CD, IL-17inhibitors were not only ineffective, but also associated with adverse events and CD deterioration [14]

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Importantly, this hypothesis must be distinguished from ongoing inflammation, small-fiber neuropathy, and residual immune-mediated tissue damage (197200)

doi: 10.3390/MOLECULES25225243 293 SafeSJayaramanAChapkinRSHowardMMohankumarKShresthaR