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10.1038/s42255-020-00338-8 156 NitzK.LacyM.AtzlerD

Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers

Through EMT, epithelial cells lose cell polarity, connections to the basement membrane and other epithelial phenotypes, and gain mesenchymal phenotypes such as increased migratory and invasive abilities, anti-apoptotic features and the capacity to degrade the extracellular matrix (79)

Impact of albumin-to-creatinine ratio point-of-care testing on the diagnosis and management of diabetic kidney disease

Redox disturbance in the endothelium can also be caused by AGEs that accumulate on the surface of stored RBCs, since they can interact with their receptor in the microvasculature, induce ROS production, and deplete antioxidant powers ( It should not be omitted that the interaction of RBCs with vascular function is predominantly through nitric oxide (NO) metabolism

Many substances being discussed have enthusiastic supporters as well as critics who point to limited human clinical data