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EClinicalMedicine 40 , 101125 (2021)

Rao AD, Sugar EA, Chang DT, Goodman KA, Hacker-Prietz A, Rosati LM, Columbo L, O'Reilly E, Fisher GA, Zheng L, Pai JS, Griffith ME, Laheru DA, Iacobuzio-Donahue CA, Wolfgang CL, Koong AC , Herman JM

Autophagic deficits in PD are also found in immune cells, which is particularly relevant because microglia are the predominant cell type responsible for clearing aggregated -synuclein in the CNS [142]

2022;55:e13158

Adipocytes and bone marrow stromal cells in the TME can promote the resistance of tumor cells to ASNase treatment by supplying Gln and cysteine to leukemia cells, 348,349 and cancer-associated fibroblasts can secrete Asp to promote solid tumor growth

Correcting deficiencies can be the missing piece for those who have tried other methods with limited success