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Among their protective and therapeutic effects against IBDs demonstrated in vitro and in DSS-induced UC mice models, the studies have shown that this compound is able to ameliorate NLRP3 inflammasome activity [369], by reducing myeloperoxidases and proinflammatory cytokines [370] and also through modulating NF-kB activation while reducing intercellular adhesion molecules (ICAM)-1 and vascular cell adhesion molecules (VCAM) [371]

We excluded patients with DM, alcohol use, or hepatitis B/C

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