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17beta-estradiol increases expression of the oxidative stress response and DNA repair protein apurinic endonuclease (Ape1) in the cerebral cortex of female mice following hypoxia

10.1016/j.celrep.2020.02.049 49 FengH.StockwellB

44 The ironsulfur cluster proteins CDGSH iron domain 1 (CISD1/mitoNEET) and CISD2 inhibit ferroptosis by reducing mitochondrial iron uptake

These results suggested that high energy intake during gestation may exacerbate oxidative stress in late gestation, whereas increased amino acid intake may enhance the bodys antioxidant capacity

As proof of principle, a broad-spectrum anti-angiogenic inhibitor (suramin), a vascular disrupting agent (combretastatin), and a combination of a gamma secretase and VEGF inhibitor were tested on VEGF established cords

Furthermore, the liver participates in converting B12 into its active coenzyme forms: methylcobalamin and adenosylcobalamin