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Ghaly G, Tallima H, Dabbish E, Badr ElDin N, Abd El-Rahman MK, Ibrahim MA, et al

Chromosomal rearrangements, mitotic recombination, point mutations, and epigenetic events like promoter methylation can inactivate tumour suppressor genes [309]

Compounds such as Britanin have shown promise in preclinical studies for their ability to modulate angiogenesis and inhibit tumor growth in various gastrointestinal cancers ( In conclusion, targeting angiogenesis presents a multifaceted approach to the treatment of gastrointestinal tumors