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To evaluate whether mutants deficient in different glutathione-dependent enzymes are impacted by TMHT, we subjected cytosolic glutaredoxin mutants to TMHT (Figure 4C)

Coupled with endogenous reactive oxygen species (ROS) generated as by-products of various cellular processes, strict regulation of antioxidants is critical to maintaining a balanced reduction/oxidation (redox) state

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FDA's concerns include potential immunogenicity for certain administration routes, peptide-related impurities, and the fact that Ipamorelin acetate contains unnatural amino acids that add characterization complexity

Differential expression analysis was performed in R studio (R version 3.6.3) using the DESeq2 package with a q-value 1.5