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Ann N Y Acad Sci 884:114 Coradini PP, Cigana L, Selistre SG, Rosito LS, Brunetto AL (2007) Ototoxicity from cisplatin therapy in childhood cancer

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B12 plays a part in the process that resets neurotransmitters so it may be that this process starts working more efficiently all of a sudden but the brain takes a while to catch up - I think of that as being like listening to an old analogue radio and having it turned up to full volume because the signal is weak

The copper atom is bound to three of the nitrogen atoms in the tripeptide