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Phase 2, multicenter, open-label study of tigatuzumab (CS-1008), a humanized monoclonal antibody targeting death receptor 5, in combination with gemcitabine in chemotherapy-naive patients with unresectable or metastatic pancreatic cancer

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Additional changes induced in response to R001 include the early p21 induction and the downregulation of Cdc25C [49] and Cyclin D1, which collectively perturbed cell cycle progression, including causing cell accumulation at both G1 (58.4 vs 38.9) and G2 (20.2 vs 10.8), with and a decrease in the S-phase population (20.5 vs 49.8) for MDA-MB-231, and largely an accumulation of cells in the G2 phase (21 vs 10.8) for MDA-MB-468, comparing treated to untreated, (DMSO) control