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Mechanism Diagram GHK-Cu vs Growth Peptides (Key Differences) GHK-Cu - Copper binding tripeptide - Acts locally in tissue - Modulates gene expression and ECM remodelling - Not endocrine - Does not elevate GH or IGF-1 GH Secretagogues (e.g., Ipamorelin, Hexarelin, MK-677) - Act via endocrine receptors - Stimulate systemic GH release - Increase IGF-1 - Primarily hormonal These compounds operate in completely different biological domains

The anti-inflammatory pathways are primarily mediated by the farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 (TGR5) 147

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2017 Jun;36(2):79-85

But by walking through the mechanisms, early data, and practical considerations, we can at least distinguish biochemical plausibility from marketing hype