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With the development of IR, an unfavorable, reverse flux of FFAs toward non-adipose tissues, such as the liver, occurs

Stem Cells Transl Med [Internet]

In situations when there is poor insulin response such as type 2 diabetes mellitus or insulin resistance, the process of gluconeogenesis continues even in the fed state, thus, further compounding hyperglycemia (32)

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For final OCR values after each titration, the OCR was calculated by taking the average value from the chamber with Amplex UltraRed and the chamber with TMRM for each sample