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This is due to several factors that differ between the controlled conditions of in vitro studies and the complex biological processes in living organisms, including interactions between different cell types, organ systems, and environmental variables (e.g., gut microbiota or circulation) that can influence how a drug works

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Capece U, et al

A 2021 study in Gut found that long COVID patients had significantly reduced microbiome diversity and specific depletions in beneficial species, including Faecalibacterium prausnitzii and Bifidobacterium bacteria known for their anti-inflammatory and immune-regulatory properties

In this regard, increases in PD frontal cortex of specific PS species have been observed, namely PS with 36:1, 36:2, and 38:3 fatty acyl side chains