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Current research has not yet fully elucidated why TINs exhibit both susceptibility and resistance to ferroptosis across different tumor types or even within the same tumor model

In addition to mitochondrial dysfunction, lipid dysregulation is another hallmark of ALS pathology (Abdel-Khalik et al., 2017)

At the methodological level, isotope tracing technologies can directly resolve actual metabolic flux changes, single-cell and spatial multi-omics can help identify cell-cell interactions and substrate competition in the tissue microenvironment, and genome-scale metabolic modeling can be used for priority ranking and assessment of targetability

Ectopic expression of MT1 and MT2 (from Brassica campestris ) in A

Another study also elucidated that AARS1 can function as a lactate sensor, catalyzing the generation of lactate-AMP, and mediating the lactylation of p53, and the lactylation of p53 will inhibit its liquid-liquid phase separation, DNA binding capabilities, and ultimately lead to a decrease in transcriptional activity, fostering the onset and development of tumors

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