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Inactivation of YAP oncoprotein by the hippo pathway is involved in cell contact inhibition and tissue growth control

As we age, NAD levels decrease, contributing to an age-associated decline in mitochondrial function, muscle regeneration and more

Lee DW, Bueso-Ramos CE, Carroll M, Whichard Z, Feng Y, Stein P, Jensen SA, Kornblau SM , Corey SJ

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Though these are a normal part of human metabolism, they cause significant oxidative stress over time, damaging DNA inside cells and leading to premature aging