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Ferroptosis and cancer BAP1-mediated regulation of ferroptosis The BAP1 gene, associated with the suppression of tumors, encodes a nuclear deubiquitinating (DUB) enzyme that forms the polycomb repressive deubiquitinase (PR-DUB) complex

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A key protective mechanism involves the oxidation of redox-sensitive cysteine residues on Keap1 notably Cys151, Cys273, and Cys288