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Surgeon General , CDC , FDA , AMA, World Health Organization , and the National Institute on Drug Abuse , classifies nicotine as the primary addictive compound in tobacco products.[7] Clinical reports have documented patients who, despite never smoking, developed severe dependence on nicotine gum

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To those arguments, other speakers, including USC epidemiologist Jessica Barrington-Trimis, countered that the risk factors for young people included not only a hard-to-quit nicotine dependence especially with nicotine salts being used in vape cartridges to smooth out the taste but negative cognitive effects for a developing brain

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The FDAs proposed rule would extend the agencys authority over other products, such as pipe tobacco, cigars, hookah and nicotine gels, as well as e-cigarettes battery-operated tubes that turn liquid nicotine and other chemicals into an aerosol that is inhaled