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Initial clinical failures, like that seen with VNP20009, have enlightened: a bacterial therapy for maximal efficacy should not be based on the removal of overall virulence, but on fine-tuned spatiotemporal control, provided by tools such as synthetic gene circuits (e.g., SLC and Cello)

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PEDF is only highly expressed in undifferentiated human retinal cells, like Y79 retinoblastoma cells, but is either absent or down-regulated in their differentiated counterparts

Importantly, it is the only reversible lipid post-translational modification (PTM) identified to date 13 and thus can dynamically regulate the function of proteins

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Vitamin D can help with mood and depression as well as help treat hypertension