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Biomater Sci (2020) 8(12):343042

In the symptomatic group, the manifestation of COVID-19 symptoms occurred predominantly in the first and third trimesters of pregnancy (35.7%), with 28.6% of pregnant women presenting the infection in the second trimester

The loss of WIPI2 function also causes a neurodevelopmental disorder that includes developmental delay, speech and language impairment, and cardiac, neurological, thyroid and skeletal abnormalities 44

Twice-daily dosing during the first 1-2 weeks followed by once-daily dosing is a commonly described approach in the research community