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The therapeutic activity of MoO 3-x -NUs in the tumor microenvironment first triggers catalase-like activity to dismutate H 2 O 2 O 2

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Unexpectedly, and in contrast to observations in fibroblasts, ACLY and ACSS2 double knockout (DKO) cancer cells remain viable and proliferate, maintain pools of cytosolic acetyl-CoA, and are competent to acetylate proteins in both cytosolic and nuclear compartments