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3C, lower right)

The cluster analysis was performed with the Genesis software ( Volcano plots were generated with GraphPad Prism 8 software or in Python using Seaborn and Matplotlib packages for genes with normalized reads, with -log 10 adj p -values on the y -axis and log 2 FC values on the x -axis

Mitochondrial dysfunction Imbalance of oxidation and antioxidation Mitochondrial ROS produced through the respiratory chain is the major source of ROS (Fig